ISSN 1004-4140
CN 11-3017/P
Volume 18 Issue 4
Dec.  2009
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FAN Xu, GUO Zhi-rui, CAO Min, ZHOU Xue-feng, GU Ning. Contrast Agents for Computed Tomography Based on Gold Nanoparticles[J]. CT Theory and Applications, 2009, 18(4): 15-25.
Citation: FAN Xu, GUO Zhi-rui, CAO Min, ZHOU Xue-feng, GU Ning. Contrast Agents for Computed Tomography Based on Gold Nanoparticles[J]. CT Theory and Applications, 2009, 18(4): 15-25.
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Contrast Agents for Computed Tomography Based on Gold Nanoparticles

  • 1. Suzhou Key Lab of Biomaterial and Technology, Suzhou Research Insistute of Southeast University, Suzhou 215123, China;

  • 2. State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China;

  • 3. Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210096, China;

  • 4. The Institute of CardioVascular Disease, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

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  • Received Date: July 02, 2009
  • Available Online: December 14, 2022
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    • Abstract
  • Gold nanoparticles hold excellent surface properties,multiple synthestic routes and good biocompatibility.Currently,the commercial clinical Computed Tomography(CT)contrast agents are iodine based organic molecules.Compared with iodine,Gold has a larger atomic number and X-ray absorption coefficient.In recent years,quite a few works about using gold nanoparticles as CT contrast agents have been published.In this review,We outlined the synthesis routes,surface modification,and the behaviors of gold nanoparticles as CT contrast agents.We emphasized the tryout of PEG,gum arabic,gadolinium chelate,and high-density lipoproteins etc.as surfactant to coat gold nanoparticles for CT imaging.We also discussed the existent problems of the newly developed contrast agents and looked forward to the future of them.
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