Abstract: Objective: To improve the ability of CT diagnosis of gastrointestinal stromal tumors (GIST) through analyzing imaging findings of GIST. Methods: Plain and enhanced spiral CT scan: was performed in 32 patients with GIST which were proved by operation and pathology. Results: All 32 cases originated single, 17 were located in stomach, 7 in jejunum and ileum, 3 in colon and rectum, 1 in esophagus, 2 in and 2 in duodenum and posterior peritoneum. 9 cases were benign and 23 cases were malignant in 32 cases with GIST. The imaging appearance of CT included submucous hypervascular lesions with predominating exophytic growth. There were obvious necrosis, cystic changes or calcification within the mass. The degree of enhanced CT were more marked in venous phase compared with that in arterial phase. Conclusion: CT is useful imaging technique in the diagnosis of GIST. The imaging findings of CT can reveal some characteristic signs of GIST. CT can precisely localized GIST and is helpful in differentiating benign with malignant GIST. The imaging of CT has important value in differential diagnosis, however, the qualitative diagnosis needs depend on immunohistochemical and eleetronmicroscopic examinations.