基于VBM的AD患者整体认知水平与脑灰质容积关系的横断面研究

陈蕊森; 夏军; 陈建良; 李爱东; 李翔

doi:10.15953/j.1004-4140.2018.27.06.04

基于VBM的AD患者整体认知水平与脑灰质容积关系的横断面研究

1. 深圳市第二人民医院(深圳大学第一附属医院)放射科, 广东深圳 518035;
2. 中山大学第八附属医院, 广东深圳 518033;
3. 中科院深圳先进技术研究院, 广东深圳 518055

基金项目:

深圳市科创委科技计划基础研究项目（JCYJ20150529153646078；CYJ20170818164405101）。

详细信息

作者简介:
陈蕊森(1993-),男,深圳市第二人民医院(深圳大学第一附属医院)住院医师,主要从事中枢神经系统影像诊断,Tel:13168477012;E-mail:13168477012@163.com;陈建良^*,男,中山大学第八附属医院主任医师,主要从事神经系统疾病诊断治疗,研究脑外伤与脑循环障碍及颅底外科技术,Tel:1390297406,E-mail:Chenjl7777@163.com。

中图分类号: R445
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出版历程
- 收稿日期: 2018-08-17
- 网络出版日期: 2021-11-07

Cross-sectional Study on the Relationship Between Integral Cognitive Level and Gray Matter Volume in Patients with Alzheimer's Disease Based on VBM

1. The First Affiliated Hospital of Shenzhen University, Shenzhen second people's hospital, Shenzhen 518035, China;
2. The Eighth Affiliated Hospital, SUN YAT-SEN University, Shenzhen 518033, China;
3. Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen 518055, China

摘要

摘要: 目的：探讨阿尔茨海默病（AD）患者脑灰质容积与整体认知功能水平的关系。方法：收集AD患者20例，MCI患者17例，健康老年对照组（NC）12例，在1.5T MR扫描仪上行T1-3DBRAVO （brain volume）序列检查，利用VBM测出脑灰质容积，行MMSE检查并得出评分，将脑灰质容积与MMSE评分进行多元回归分析，以及运用ROC曲线对所有患者脑灰质容积的诊断效能进行评价分析。结果：所有受试者随着脑灰质容积减少，MMSE评分也减少，脑灰质容积每减少10 mL，MMSE评分下降0.57分（P<0.01），男性患者与低龄组下降的幅度更显著。所有患者脑灰质容积ROC曲线AUC为0.927，最佳阈值为538.49 mL，特异度为90.0%，敏感度为84.6%。结论：所有受试者脑灰质容积下降，整体认知功能水平也下降；所有患者与对照组脑灰质容积可以反映整体认知功能水平，脑灰质容积测量对AD的诊断可提供有价值的信息。
- 阿尔茨海默病 /
- 认知障碍 /
- 磁共振成像
Abstract: Objective: To explore the relationship between integral cognitive level and gray matter volume in Alzheimer's disease (AD). Methods: 20 AD patients, 17 MCI patients and 12 healthy old persons were in this study.All subjects were examined by T1-3 D BRAVO (brain volume) sequence in 1.5 T magnetic resonance scanner. The volume of gray matter was measured with Voxel-based morphometry (VBM). All subjects were underwent MMSE and obtained the score of MMSE. The multiple regression analysis of gray matter volume were compared with MMSE score. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of gray matter volume in AD. Results: All of the subjects with reduced gray matter volume of brain, also reduce the MMSE score, gray matter volume decreased by 10 m L and MMSE score decreased by 0.56 points (P<0.01). The decline was more pronounced in men and in younger groups. The area under the curve (AUC) of the gray matter volume was 0.927. The optimum threshold was 538.49 m L, the specificity was 90.0% and the sensitivity was 84.6%. Conclusion: As the volume of gray matter decreased, the level of integral cognition also decreased. The gray matter volume in all patients and control group could reflect the integral cognitive level. The measurement of gray matter volume in the brain could provide valuable information for the diagnosis of AD.
- Alzheimer's disease /
- cognition disorders /
- magnetic resonance imaging

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基于VBM的AD患者整体认知水平与脑灰质容积关系的横断面研究

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出版历程

Cross-sectional Study on the Relationship Between Integral Cognitive Level and Gray Matter Volume in Patients with Alzheimer's Disease Based on VBM

期刊类型引用(6)

其他类型引用(4)

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出版历程

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