Abstract: Objective: To evaluate value of low-tube-voltage dual-source computed tomographic coronary angiography(CTCA) for diagnosis of coronary luminal stenosis in comparison with conventional coronary angiography(CAG). Methods: 52 patients who suspected for coronary disease underwent dual-source CTCA and CAG examinations. The agreement between the CTCA and CAG in assessing the coronary luminal stenosis was assessed. Sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy for significant stenosis in CTCA(＞50%) were also assessed. Result: The agreement between the CTCA and CAG in assessing coronary luminal stenosis was good(kappa value = 0.839). The sensitivity, specificity, PPV, NPV and accuracy for significant coronary luminal stenosis based on coronary branch were 97.2%, 95.2%, 89.1%, 97.6% and 96.2%, respectively, and the sensitivity, specificity, PPV, NPV and accuracy for significant coronary luminal stenosis based on coronary segment were 98.1%, 96.3%, 92.7%, 99.0% and 96.8%, respectively. Conclusion: There is a good value in diagnosis of coronary luminal stenosis in CTCA with low-tube-voltage setting, which is worth to application and generalization.