Abstract: With the development of CT technology,reconstruction speed has become an important indicator of CT systems,and the research of acceleration image reconstruction has become a hotspot in CT.For the Harvard architecture,dedicated hardware multiplier and the extensive use of pipelining,etc.,DSP has been applied to acceleration image reconstruction.In this paper,the method of acceleration three-dimensional cone-beam CT image reconstruction using DSP is researched.Firstly,the situation that DSP is used in image reconstruction is introduced.Secondly,an acceleration CT image reconstruction technique based on DSP is presented though the decomposition of the typical three-dimensional reconstruction algorithm-FDK,combined with the characteristics of the hardware structure of DSP.The hardware architecture and soft pipelining are fully utilized with C optimization,assembler optimization and compiler optimization.Finally,the acceleration computing of CT image reconstruction is achieved with TMS320C6455 chip.The experimental results show that the method achieved higher speedup.