Abstract: Objective To study the radiographic findings in the diagnosis of open-negative Tuberculosis syndrome. Materials and Methods 42 tuberculosis patients of open-negative syndrome proved by etiology or clinicl treatment were examined by X-ray film and CT. Results Mottling and patchy in filtration were observed in 42 patients, irregular shape cavities in 41 Patients, 28 patients had satellite lesions, 8 with fibrotic stripe, 10 had mottling calcifications, 2 had lymph node enlargement Conclusion CT scan is a valuable method in the diagnosis of open-negative syndrome, especially evaluating lesions of cavity, posterior-heart posterior-costophrenic angle, overlapped by hilum of lung, and so on.