Abstract: Objective To evaluate the value of clinical application of contrast-enhanced ultrasound and 16 multislice scan in diagnosis of liver neoplasms. Methods The features of three different typical images of three different phases in 30 patients with liver neoplasm detected respectively by contrast-enhanced ultrasound and 16 multislice scan were compared and analyzed.The ultrasound contrast agent,“Quanfuxian”,was taken by intravenous injection.The different images of three phases were investigated by coherent harmonic imaging.And the high-quality scan mode was adopted by 16 multislice scan.7.5-mm-thick-section,through division of 1.25mm-section,1.375:1-pitch,120 KA-voltage and 280mA-tube current were set.The contrast medium was injected for the three enhanced scan phases.The arterial phase was defined as 16-25s,the portal vein phase at 35-55s and the delayed phase at 1min and 10s-3min.The monophase injection of non-ionic contrast agents was utilized by high-pressure syringes.The injection rate,the dosage and the concentration of contrast agent were 2.5ml/s,70-85ml and 300mg/ml respectively. Results : 18,5,3,3 and 1 out of 30 patients with liver neoplasms were diagnosed as small hepatocellular carcinoma,small vessels neoplasm,focal hepatic adipose infiltration,metastatic hepatic carcinoma and cataplasia nodus,respectively using contrast-enhanced ultrasound and 16 multislice scan.All cases were confirmed by pathological examinations after the operation and puncturatio.Among them,2 cases were not observed any typical image changes of liver neoplasms using contrast-enhanced ultrasound,but verified by 16 multislice scan as 1 small hepatocellular carcinoma and 1 cataplasia nodus. Conclusion Both contrast-enhanced ultrasound and 16 multislice scan have high potentiality of clinical application in diagnosis and differential diagnosis of liver neoplasms.But for some unusual patients with liver neoplasms,the combination should improve the early diagnostic ratio.