Abstract: Objective: Investigate the CT value changes of creeping fat around the intestinal segment in Crohn's disease(CD).Methods: From January 2010 to March 2019, 31 patients with active CD(study group) and 31 age and gender matched inactive CD patients/healthy people(control group) were enrolled in the study.The people of study group and control group were tested for CT values of mesentery near the inflammatory intestinal wall, including CT values in plain scan, arterial phase, venous phase and delayed phase.Clinical data including enteroscopy and its pathological results, and clinical immunosuppressive therapy were collected.Results: There were 31 patients(26 males and 5 females) with active Crohn's disease(CD) in the study group.There were 31 patients(22 males and 11 females) in control group.The CT value of creeping fat in patients with Crohn's disease in active stage is higher than that in inactive CD patients/healthy people, and there may be sustained mild enhancement after enhancement over time.Conclusion: The creeping fat along the mesenteric border of bowel inflamed segments of CD can be denser and continuously strengthened during the active stage of the disease, so the change of CT value of the creeping fat around the intestinal tube has diagnostic value for Crohn's disease activity.