Abstract: Objective: To explore the applicative value of 3 different intestinal preparation methods in CT enterography (CTE). Methods: A prospective study was conducted in 156 patients which were suspected of small intestinal lesions and underwent CTE. 156 cases were randomly divided into group A, B and C with 52 cases in each group. The intestinal contrast agents were taken orally all. Group A and B ate semi-liquid diet 16 hours before scanning, and took 6g of senna leaf for catharsis. They fasted for 12 hours before scanning, and Group A tried to take isotonic mannitol every 15 minutes from 1 hour before scanning, Group B tried to take drinking water as much as possible by the same way. Group C fasted for 6 hours before scanning and tried to take drinking water every 15 minutes from 1 hour before scanning. CTE was performed in all three groups 10 minutes after oral administration of contrast agent. The filling effect of small intestine and the diagnostic value for small intestinal lesions in 3 groups were compared respectively. Results: The filling effect of small intestinal in group A was the best, followed by group B, and group C was the worst. The diagnostic results of small intestinal lesions showed that group A had significant diagnostic value for all segments of small intestine lesions; group B had obvious diagnostic value for duodenal and jejunal lesions, but the diagnostic effect for small lesions of distal ileal was poor; group C had satisfactive diagnosticeffect for duodenal and upper jejunal lesions, but was not conducive to reveal small lesions of distal ileal. Conclusion: Full intestinal preparation is the important technical factor of CTE, and take isotonic mannitol filling intestine as much as possible is conducive to reveal intestinal lesions, which is a safe, reliable, cheap and convenient intestinal preparation method.