Abstract: To evaluate the effects of different concentrations of iodine contrast agent on MSCT hepatic artery enhancement. Methods: A total of 328 patients who underwent enhanced CT scan of the upper abdomen were selected as study subjects. According to different concentrations of contrast agents, they were divided into study group and control group. The study group received 400mgI/mL contrast agent, while the control group received 370mgI/mL contrast agent. The injection flow rate of the contrast agent was 2.5mL/s. All patients underwent three-phase enhanced scan of the liver and reconstruction of the hepatic artery. The enhancement value of abdominal aorta at different levels, the display rate of various branches of hepatic artery and the image quality of hepatic artery were compared between the two groups. Results: The enhancement values of hepatic portal level, peritoneal trunk level and renal artery level in the study group were significantly higher than those in the control group. There was no significant difference in the rate of hepatic arterial branches between the study group and the control group. There were statistically significant differences in the image quality scores of the study group and the control group. The image quality of the hepatic artery in the 400 group was more clear and sharp than that of the control group. Conclusion: The dose of contrast agent is determined by body surface area, which is beneficial to individual use of contrast agent. The use of 400mgI/mL contrast agent can reduce the dose of contrast agent, improve the strengthening efficiency of abdominal aorta and optimize the image quality of liver artery, which is worthy of clinical promotion.