Abstract: Objectives: To evaluate the consistency of energy spectrum CT virtual non-contrast and non-contrast scan on the density of subsolid lung adenocarcinoma (CT value); and the value of enhancement scan on the invasiveness of subsolid lung adenocarcinoma. Methods: 46 patients with subsolid nodules on chest CT first time and then scanning spectrum CT enhancement. A total of 45 nodules with pathologically confirmed lung adenocarcinoma and precancerous lesions were enrolled in 39 patients. Obtain virtual non-contrast images at the workstation, compare the average HU values of the regions of interest in the lesions, surrounding normal lung tissue and paravertebral muscles. According to the prognosis and invasiveness, divided into the precancerous lesions, the minimally invasive adenocarcinoma group and the invasive adenocarcinoma group, which compared there difference. Results: There was no significant difference between the non-contrast and virtual non-contrast of the surrounding normal lung tissues and paravertebral muscles, which were highly correlated. There was no significant difference in HU and iodine concentration. There was no positive results in the invasiveness of lung adenocarcinoma between the groups of the precancerous lesions, the minimally invasive adenocarcinoma and the invasive adenocarcinoma. Conclusion: There was no statistically significant difference between the energy spectrum CT virtual non-contrast HU value and the non-contrast scan. The enhancement scan had no positive results in identifying the invasiveness of lung adenocarcinoma in this group.