Abstract: Objective: To investigate the relationship between ground glass opacity and the pathologic climax-like growth in patients with stage I invasive lung adenocarcinoma by three-dimensional CT. Methods: A total of 168 patients with stage inⅠ vasive pulmonary adenocarcinoma who were treated from June 2013 to June 2017 were selected. The components of ground glass in stage Ⅰinvasive lung adenocarcinoma were calculated by three-dimensional CT quantitative analysis software and the largest radial line measurement ratio, semi-quantitative assessment of the invasive growth of the adherent adenocarcinoma composition, and the correlation between the two. Results: The proportion of ground glass components was(0.21±0.18), the percentage of ground glass components was(0.44±0.36), the semi-quantitative analysis of pathological sections the ratio was(0.29±0.24). There was a positive correlation between the proportion of ground glass components and the proportion of climax-like growth components(r=0.634 and 0.598, P=0.000) by three-dimensional CT quantitative analysis and maximum diameter line analysis. The ratio of ground glass to the ratio of ground-glass components measured by the maximum diameter method was 3.8%. Outside the 95% confidence interval, the three-dimensional CT value was 4.4%. There was no significant difference between the two methods(P>0.05). Conclusion: The three-dimensional quantitative analysis of stage I invasive lung adenocarcinoma patients with ground-glass components and climax-like growth component has a significant correlation, which has a significant clinical significance in the diagnosis of secondary pathology, and compared to the maximum diameter method is more comprehensive reflect the stage I invasive lung adenocarcinoma of the tumor status.