Abstract: When the cap rock above the reservoir containing thick source rocks and other special strata, the reflection of the overlying strata will show strong amplitude, it will hide the reservoir information and make it present as a weak reflection, thereby interference normal description and prediction of reservoir. Therefore, eliminating the effect of interference layer on seismic reflection of reservoir, enhancing weak reflection signal is very important to improve the accuracy of reservoir prediction and determine the distribution of reservoir space. Fan 159 well block is located in the Midwest Fandong area. In this area, it containing high resistance and high speed thick hydrocarbon source rocks above the reservoir, it has a strong effect on the underlying reservoir, and it must be stripped. In this paper, we use F159 area as an example, analyses the geophysical characteristics of reservoir, study the matching pursuit algorithm based on horizon control, and finally peel off the strong shielding layer. We compared the section attributes and horizon attributes, it can be found that the recognition accuracy of reservoir is obviously improved.