Abstract: Objective: To explore the influence of right coronary artery severe stenosis on left ventricular global and regional function. Methods: Coronary CT angiography was performed by 128-slice spiral CT. The patients with coronary artery stenoses more than 75% verified by coronary angiography, were considered as lesion group, and the patients of no coronary artery stenosis as control group. The row data were set 10 phases from 0% to 90% with 10% of R-R interval, and left ventricular ESV, EDV, and EF was measured and calculated, and all data were compared in two groups. All short axial images were reconstructed, then inferior wall thickness and inferoseptal wall thickness were measured, the percentual systolic wall thickening was calculated in end systolic and end diastolic phase of all groups, respectively, the statistical differences were analyzed in the different groups. Results: Compared with ESF and EF of control group, there were statistical differences in those of lesion group, <i<P</i< < 0.001, and EDV of two groups had no significant differences. EDWT of inferoseptal segment in lesion group had a statistically significance, <i<P</i< < 0.05, and there were no significant differences in ESWT of inferoseptal segments, EDWT and ESWT of inferior segments. Comparison of SWT in two groups had significant differences in inferior and inferoseptal wall segments, <i<P</i< < 0.001. Conclusion: severe stenosis of right coronary artery results in reduction of LVEF and SWT in inferior and inferoseptal wall segments, further, regional diastolic function of inferoseptal wall segments are decreased.