Abstract: Objective: To improve knowledge and imaging diagnosis of bone epithelioid hemangioendothelioma(EHE). Methods: We retrospectively analyzed X-ray, CT, MR and pathological data of six cases of bone epithelioid hemangioendothelioma which confirmed by operation and pathology, and summarize its imaging features. Results: Three patients' lesions, characterized by multiple osteolytic destruction, were located in distal femur, tibia, fibula and foot. Two cases of lesions were located in the lower tibia. One case of lesion was located in the proximal femur. The imaging features of X-ray and CT of these lesions were multifocal osteolytic bone destruction, hardening of the edge and there were fence-like lesions bone crests in part of the lesions. MR image features of these lesions were slightly long T1 WI and long T2 WI, and they had significant enhancement after contrast-enhanced scanning. Immunohistochemical studies showed that tumor cells CD3 l, Vimentin, CK(+), CD69(Spotty+), CD163(spot), FLI-1(+), Ki67(+<10%). Conclusion: EHE have some imaging characteristics. CT and MR imaging can provide valuable information for clinical diagnosis and differential diagnosis.