Abstract: Purpose : To use HRCT to increase the diagnostic reability of lacuna infarction of brain. Materials and methods: HRCT were used to the basal ganglion or suspected areae in patients with lacuna suspected clinically. HRCT were performed at the same layer or 1~2 mm above or below this layer when lacuna lesions were difficult to distinguish from image point grains. Results:In 208 patients lacuna lesions were found in conventional CT. In 320 cases with suspected lesions, he lacuna lesions and false ones (image point grains) were diagnosed with HRCT in 89 and 231 cases respectively. In addition. the HRCT images of normal brain structure were more clear compared to those obtained in conventional CT Conclusion: Not only HRCT can increase the diagnostic rate of lacuna infarction of brain. but also distinguish the false lacuna,HRCT is a better technique that complements the insufficiency of conventional CT in the diagnosis or lacuna.