Abstract: Objective: Comparative analysis of multi slice spiral CT coronary angiography (CTA) and digital subtraction angiography (DSA) in the accuracy and sensitivity of evaluating coronary artery stenosis, in order to explore the clinical value of CTA for detecting coronary artery stenosis. Methods: 39 patients were diagnosed or suspected with coronary heart disease from 2011 September to 2013 September in our hospital. They were examined by CTA, and DSA within two week before or after the CTA examination. Then the CTA and DSA test results were compared and analyzed, the specificity and sensitivity of CTA and DSA of coronary artery were figured out. Results: 39 patients with 290 vessels, CTA found 220 coronary artery stenosis; DSA found 223 coronary artery stenosis. With DSA as the standard, the sensitivity, specificity, positive predictive value, negative predictive value and the detective accuracy of CTA detection is 92.44%, 96.15%, 97.35%, 93.46% and 94.96%. Conclusion: CTA can clearly show the changes of coronary artery wall thickening and stenosis, aortic wall plaque and calcification. It is an noninvasive method for the diagnosis of coronary artery disease.