Abstract: Objective: To evaluate the accuracy of the staging of the colorectal cancer, T, N by describing the evaluation of contrast-enhanced CTC, comparing the clinical pathological staging and clarify its clinical application value. Methods: In the study, 40 patients are selected, contracting non metastatic colorectal cancer, who were performed the scan of contrast-enhanced CTC, the tube voltage is 120 kV and the tube current is 300 mA. Evaluate the clinical staging, make comparison with the pathological staging, calculate the coincidence of T and N staging and conduct consistency test, only to draw a conclusion that there is statistical significance(<i<P</i<〈0.05). Results: The coincidence rate of T staging is 77.5%, which is favorable(<i<k</i< = 0.665, <i<P</i< = 0.000), and the coincidence rate of N staging is 82.5%, which is more favorable,(<i<k</i< = 0.734, <i<P</i< = 0.000), and the total coincidence rate is 67.5%. Conclusion: The contrast-enhanced CTC can be applied in the evolution of colorectal cancer before surgery, especially can help the clinical staging accurately, and have some important clinical values in determining therapeutic methods and evaluating the prognosis of the patients.