Abstract: Objective:To study the diagnostic value of quantitative T1WI MR parametric perfusion-weighted imaging based on DCE-MRI in duct-borne breast cancer.Methods:16 cases of female were performed the DCE-MRI examination before surgical operation,and the time-intensity curve(TIC) were acquired,then the parameters perfusion images of Wash-in,Wash-out,TTP,MIPt and PEI were drawn out by the special software for breast.And then measured the parameters of perfusion,analyzed the features of perfusion of duct related breast cancers.Results:13 cases invasive ductal carcinoma and 3 cases ductal carcinoma in situ were confirmed by pathology in the 16 cases.13 cases were non-mass-like enhancement,such as 7 cases duct-like,5 cases patchy,1 case spot-like.Another 3 cases were mass enhancement.All of the 16 cases TIC were the type II.13,10,9,15 and 16 lesions were found in the five kinds of parametric images.The detection rates were 81.25%,62.50%,56.25%,93.75% and 100%,respectively.We found the parameters between lesions and normal breast tissue were significant difference(P<0.001).Moreover,the parameters between periphery and centre of lesions was also significant(P<0.001),except in the TTP.But there's no significant difference between the invasive ductal carcinoma and the ductal carcinoma in situ.Conclusion:Quantitative T1WI MR parametric perfusion-weighted imaging based on DCE-MRI has a high detection rate of the duct-borne breast cancers,and might provide important additional information for its diagnosis and differential diagnosis.