Abstract: Objects:To evaluate the clinical application value in the assessment of HCM by dual-source CT(DSCT).Methods:The clinical dada and DSCT imaging of 10 cases with confirmed HCM and 13 normal controls were analyzed retrospectively.Results:10 cases of HCM including asymmetric HCM(n=9),symmetric HCM(n=1) were clearly diagnosed by DSCT,and one of asymmetric HCM was accompanied by LVOT.The thickness of interventricular septum,anterior wall and apical in the HCM group were significantly greater than in the control group,while there were no significant differences in the thickness of free and posterior wall between them.The ratio of maximum wall thickness of the Left ventricular wall or apex to the PWTd in end-diastole was greater than 1.5 in the HCM group.LVIDd,LVIDs and LVOTd in the HCM group were smaller than in the control group,on the contrary,LADd in the HCM group was greater than in the control group.WT in the control group was about(57.88 5.09)%,while it reduced to(20.10 ± 4.89)% of the thickened segments in HCM group.Both MM and EF in the HCM group were greater than in the control group,instead,both EDV and ESV in the HCM group were smaller than in the control group.One case had atheromatous plaque and the degree of coronary artery stenosis was approximately 85%;7 cases had myocardial bridge(MB) and all of the MB at LAD.Conclusions:DSCT is a promising modality to assess HCM,which can provide one-stop noninvasive evaluation of cardiac morphology,function,as well as coronary artery anatomy.