Abstract: Objective: to assess the diagnostic value of MSCT angiography in acute mesenteric ischemic disease. Method: collected 30 clinical suspecting cases of acute mesenteric ischemic disease which examined with MSCTA from January 2010 to January 2013, attain arterial scanning time with manually trigger scanning, then venous phase scanning with 60 mL contrast agent and injection rate of 4 mL/s. Then transmit the thin-layer data to AW4.4 workstation to conduct MPR, CPR, VR and MIP. Results: 30 cases of acute mesenteric ischemic disease were all confirmed, 20 cases diagnosed with DSA were confirmed, showing the same result with those diagnosed with MSCTA; Among them, 14 cases were superior mesenteric artery embolism, 2 case were merged with artery dissection, 6 cases were inferior mesenteric artery embolism, 8 cases were superior mesenteric vein, 2 cases were inferior mesenteric vein. Conclusion: MSCTA is safe, fast, precise, economical and preferred diagnostic method for acute mesenteric ischemic disease; meanwhile it has important guiding value for clinical early diagnosis and early treatment.