Abstract: Objective:To evaluate the diagnostic value of dynamic enhanced MRI(DCE-MRI) for breast occupying lesions with calcification detected by mammography.Materials and methods Mammography and MRI data of 101 patients with breast occupying lesions containing calcification were retrospectively analyzed.Fifty six cases were malignant,including 46 cases with invasive ductal carcinoma,3 cases with ductal carcinoma in situ,2 cases with lobular carcinoma in situ,3 cases with mucous adenocarcinoma,1 case with basal cell carcinoma,1 case with myoepithelial carcinoma.Benign lesions were 45 cases,including 39 cases with breast fibroadenoma,4 cases with cyst,2 cases with fibrocystic breast hyperplasia.According to the diagnostic standard,the form of calcification was divided into three categories,including typical benign,suspicious and high suspicious malignant.The diagnosis of mammography and MRI was compared with the pathologic diagnosis,which was regarded as gold standard.The diagnostic results of mammography and MRI were statistically analyzed using McNemar's Test.Results 85 cases(84.2%) were correctly diagnosed,while 16 cases(15.8%) were misdiagnosed or diagnosed as suspicious malignant calcification by mammography.Among the 16 cases,14 of them were correctly diagnosed following DCE-MRI examination,total 99 cases were correctly diagnosed by DCE-MRI.The difference of diagnostic results based on mammography and MRI findings was significant(P = 0.0005,P＜ 0.05).Conclusion:When it is difficult to make a definite diagnosis for breast occupying lesions with calcification after mammography,especially for those patients with lesions in BI-RADS 3 and 4,DCE-MRI is helpful in improving diagnostic accuracy.