Abstract: Objective: For neonatal hypoxic ischemic encephalopathy(HIE) of hyperbaric oxygen(HBO) therapy,brain CT showed dynamic changes and clinical effect comparison.Methods: A retrospective analysis of 85 cases of HIE neonatal clinical data and CT before treatment,according to CT findings of the brain is divided into light,medium,heavy type 3,HBO and conventional adjuvant therapy in 1,2,3 respectively after a course of brain CT review,on 3 type CT prognosis and clinical comparison analysis.Results: 85 cases of children with HBO before treatment CT examination,in which mild HIE in 20 cases,moderate HIE in 42 cases,severe HIE complicated with cerebral hemorrhage of 23 cases;HBO and conventional adjuvant treatment after 1 courses of treatment review of CT in 9 cases,mild HIE negative,symptoms returned to normal,and 11 cases of mild and moderate,severe HIE before treatment with CT examination results slightly better,alleviation of clinical symptoms,CT total turnover rate was 11.12%(9/85);HBO and conventional adjuvant treatment after 2 courses of treatment review of CT,mild in 20 patients with HIE all negative,moderate HIE in 30 patients were negative,CT turnover rate of 58.82%(50/85),of which 12 cases of moderate and severe in 23 patients before treatment with CT examination results improved significantly,the clinical symptoms were also significantly reduced;HBO and conventional adjuvant treatment after 3 courses of treatment review of CT,mild and moderate HIE all negative,severe HIE in 12 patients were negative,CT turnover rate of 87.06%(74/85),in which severe HIE with intracerebral hemorrhage in 11 cases,CT shows hemorrhage absorbed,leaving encephalomalacia,clinical symptoms improved markedly.Conclusion: Application of CT display neonatal brain dynamic change on HBO treatment HIE have important guiding value.