Abstract: Objective:To investigate the diagnostic value of <sup<18</sup<F-FDG PET/CT in pre-operative diagnosis and post-operative follow-up of gynecological malignancies.Materials and Methods:33 patients(17 patients who were doubted malignant tumors and 16 patients who were suspected recurrence or metastasis after operation)were scanned by <sup<18</sup<F-FDG PET/CT.The results were compared with the conventional imaging modalities.Results:In 17 patients who were doubted malignant tumors,the patients-based diagnostic ability of PET/CT was similar with conventional imaging modalities.For metastasis diagnosis,the sensibility,specificity,accuracy,positive predictive value and negative predictive value of the two methods were 85.7% vs 28.6%,100% vs 100%,94.1% vs 70.6%, 100% vs 100%,90.9% vs 66.7%.The sensibility of the two methods had significant difference.And the lesion-based accuracy of PET/CT for metastasis was also significantly higher.In 16 patients who were suspected recurrence or metastasis after operation,The lesion-based sensibility,specificity,accuracy,positive predictive value and negative predictive value of the two methods were 76.9% vs 48.7%,77.8% vs 66.7%,77.1% vs 52.1%, 93.8% vs 86.4%,43.8% vs 23.1%.The sensibility and accuracy of PET/CT were higher than that of conventional imaging modalities significantly.Conclusion: <sup<18</sup<F-FDG PET/CT,as a non-invasive imaging modality,has considerable value in pre-operative diagnosis and post-operative follow-up of of gynecological malignancies.