Abstract: Objective: In the computer-aided diagnosis and treatment of the future,in order to extract a good CT liver tissue has been divided in the interest area.Methods: Using entropy segmentation algorithm for CT liver tissue region of interest of automatic segmentation,and professional doctor’s manual segmentation in the zone of interest relative ratio.Results: Segmentation of the region of interest and specialty physician’s segmentation of the region of interest,with good access to the capacity of region of interest.Conclusion: In different conditions of the liver to do the corresponding pretreatment,and then the manual segmentation of the region of interest and entropy in the corresponding data for comparison,the entropy method is very effective.