Abstract: Objective: To investigate the clinical value of the CT examination for neonatal hypoxic-ischemic encephalopathy(HIE).Data and Methods: Conduct a retrospective analysis of the clinical data and CT clinic manifestations of 45 cases of neonatal hypoxic-ischemic encephalopathy(HIE).Carry out a confirmation CT scan of the cranial bones and brains of all ill infants within 24 to 72 hours.Results: HIE is categorized into three levels:slight,medium and severe according to CT manifestations(slight,10 cases;medium,20 cases;severe,15 cases;male,26 cases,female,19 cases).Conclusions: CT examination can provide an objective basis for a clinic diagnosis,treatment and assessment of prognosis of the HIE.