Abstract: Objective: To study the clinical application value of spiral CT perfusion imaging in diagnosis of adrenal hyperplasia.Methods: Spiral CT perfusion imaging was performed in 23 healthy volunteers and 18 patients with adrenal hyperplasia.CT perfusion parameters including relative blood flow(RBF),mean transmit time(MTT)and permeability surface(PS)were analyzed.The test was used in the statistical analysis for the CT perfusion parameters.Results: RBF,MTT and PS of normal adrenal gland were 0.63±0.22 mL/100g/min,70.65±12.31 s,0.72±0.13 mL/100g/min respectively.RBF,MTT and PS of adrenal hyperplasia were 0.45±0.19 mL/100g/min,118.39±19.98 s,0.49±0.21 mL/100g/min respectively.RBV and PS in normal adrenal gland were higher than that of adrenal hyperplasia,while MTT in adrenal hyperplasia was higher than that of normal adrenal gland.There was significant difference of RBF,MTT and PS between normal adrenal gland and adrenal hyperplasia(t=15.91,20.03,9.96,respectively,P<0.05).Conclusion: Spiral CT perfusion imaging is a feasible functional examination for adrenal gland.It reflects the microcirculatory blood flow of adrenal gland and provides useful information for differential diagnosis in adrenal hyperplasia.