Abstract: Objectives: To evaluate the diagnostic value of MSCT for detecting coronary artery disease in patients with arrhythmia by compared with DSA.Methods: During January 2009 to November 2010,we collected the data of 31 patients with arrhythmic who were suspected or to have coronary artery disease to accomplishing MSCT and DSA in Coal General Hospital.The results were compared with DSA.Result: The MSCT enabled the visualization of the entire coronary tree with diagnostic image quality in 30 of the 31 patients(96.77%,30/31);The MSCT had a sensitivity of 88.46%,accuracy of 87.74%,Specificity of 87.50%,positive predictive value of 69.70%and negative predictive value of 84.34%for detecting less than 50%stenosis;while it had also a sensitivity of 98.51%,accuracy of 91.51%,Specificity of 89.22%,positive predictive value of 75.00%and negative predictive value 88.78%for detecting more than or equal 50%stenosis.Eventually statistical analysis usingχ² test showed no statistically significant difference between MSCT and DSA,χ²=0.879,p>0.05.The overall Pearson's correlation coefficient between the degree of stenosis detected by DSA and MSCT(r=0.763,p<0.01).Conclusion: Adopted appropriate measures to scanning and after processing,MSCT has excellent sensitivity for assessment coronary artery stenosis,and while has high concordance as compared with DSA,moreover it also can identify the property of plaque and detecting myocardial bridge to content the needs of clinical.