Abstract: Objective: To analyze the clinical and imaging characteristics of chronic alcoholism encephalopathy(CAE) due to Alcohol dependence,to explore the clinical diagnosis value in the disease.Methods: A retrospective analysis of clinical and CT,MRI imaging data of 32 cases complete data in patients of CAE,its imaging features were concluded.Results: CAE is characterized by different degrees of nervous system damage(especially the central nervous system) and mental disorders;the brain damage mainly shows in CT,MRI: 27 cases of brain atrophy;7 cases of cerebral infarction;18 cases of white matter demyelization;3 cases of Wernicke's encephalopathy;1 cases of Marchiafava-Bignami disease;24 cases of multiple lesions coexist.Conclusion: a) It is the mainly pathological mechanisms in CAE occurred that alcohol use leading to brain vessels damage and nutrient metabolism disorder,brain tissue ischemia and hypoxia and nerve fiber demyelinationis.b) CAE imaging has its own characteristic,especially cerebellar vermis atrophy,Wernicke's encephalopathy and Marchiafava-Bignami disease is more characteristic,there were great significance in understanding the nature,scope and degree of brain damage by CT,MRI examination.It is an important basis in the clinical diagnosis,treatment and prognosis of evalulation.