摘要:
目的:评价磁共振功能成像(fMRI)在临床医学中的应用。材料与方法:应用GE公司SignaHorizon磁共振成像系统及血氧含水平(BOLD)法,对16例脑血栓形成患者进行检查。T1加权像应用自旋回波(SE,spinecho)序列,T2*应用单次激发回波平面成像(EPI,echo plana imaqing)序列。实验采取对照—任务—对照—任务或任务—对照—任务—对照范式,应用Sun Spare工作站。有关数据处理软件以及t-检验与相关分析等统计学方法对数据进行处理。结果:对照组多数患者短期内病情稳定,停脱水降颅压药后,很快复发.只有一例四十岁男性例外。fMRI显示仅2例本组患者大脑皮质初级运动区有激活。实验组患者指疗期内病情稳定,一个疗程内功能明显恢复。fMRI显示实验组患者大脑皮质初级运动区明显激活。结论:磁共振功能成像在检测脑血栓形成患者功能恢复方面是一个客观而有效的手段,同时亦提示脑血栓形成急性期应用改善脑血管微循环药物疗效巩固,应用与不用相比有明显差别。
Abstract:
To evaluate the application of the am in the clinical medicine. Materialsand Methods:With the help of GE Signa Horizon un systen and the method of BOLD, 16 patientswere examined who suffered from the cerebral thrombosis. T1 xveighted images were obtained tvith spinecho pulse sequence, and T2* weighted images witll sillgle shot gradient echo planar unagliW pulsesequence. With the Sun Sparc workstation and related software, and stahshcal methods such as student t-test and correlation the data were analyzed. Results: The majority of the patients in the control group hada stable state in a short time after admission to hospital, and the disease reerudesced soon after stoppingthe remedy of dehydration and encephalic pressure reduction given exeept 2 younger pahents. The fMRIresults showed that there wer active areas within the brain only in 2 cases of this group. In theexperimental group, all patients had a stable state in the period of treatment and the functions of theirtroubled limbs were remarkably reeovered. With fMRI, it was also found that there were achve areas inthe primary motor cortex. Conclusion: It is an objective and effective intuentality for fMRI to inspectthe functional resumption of the pahents Who suffered from Cereral thrombosis. Besides, it is also hintedthat the curative effeet was very good When using the remedy of coreral dricro-circulation such as theginkgo biloba extract in the acute period of the disease, and was different with and without it.
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