Abstract: Objective To study CT manifestations of in spleen and to evaluate CT in their diagnosis. Materials and Methods CT manifestations of non-tumour Diseases Were retrospectively analyzed in 582 pathologically proved cases and clinic or other imaging examine cases,which included congenital develop abnormity (n=26),big spleen (n=457),lienal tranma (n=87), lienal cyst (n=4),lienal abseess(n=2),lienal infarct (n=5), and lienal tuberculosis (n=1). Results Up to 99.6% of non-tumour diseases in spleen by find out. Each disease carried its own features on CT scans. Conclusion:CT is a preferred imaging examination for this disease. CT is very helpful for the diagnosis of non-tumour diseases in spleen.