Abstract: purpose: To sum up the experiences of CT-guided percutaneous thoracic puncture biopsy. Materials and Methods: 83 cases mere performed. 70 cases were pulmonary diseases, 10 cases were mediastinal diseases, 3 cases were thoracic wall and pleural diseases. With pulmonary biopsy needle. A total of 93 cuttings were done. Results: The ratio of puncture succession was l00%. The results of cytology and histology: ideal was 80.7%, reliability was l3.3%, the total reliable ratio was 94%, unreliability was 6%. Conclusion: It could be increased the ratio of puncture succession and the reliability of tissue sample that accurate location. skilled operation and the cooperation with the patients.