Abstract: Objective To discuss differential diagnosis between gallbladder carcinoma of thick wall and chronic ccholecystitis. Methods Gallbladder carcinoma of thick wall in 15 cases and chronic cholecystitis in 15 cases proved by pathology were analysed by comparison. Results: Gallbladder wall in all cases with gallbladder carcinoma was irregular thickened. It's wall of in 6 cases were interruption after enhancement. It's caverna in 8 cases were small and normal shape were lost, It's wall in 9 cases were stiff. It's round in 10 cases were not clear, Lymph node in 7 cases were big. 15 cases chronic cholecystitis: Gallbladder wall in 2 cases were irregular thicken, gallbladder were changed small and it's wall were stiff in 2 cases. It's round in 4 cases were not clear. All one's Lymph node were not big. Conclusion: Differential diagnosis of CT have important value between gallbladder carcinoma of thick wall and chronic cholecystitis.