Abstract: <b<Objective</b< To investigate manifestations of the multi-slice CT Virtual Intravascular Endoscopy (MSCT-VIE) in the arteriosclerosis and it's diagnostic value. <b<Methods</b< 40 cases in normal group and 24 cases of arteriosclerosis group were performed volume scan with SIEMENS Sensation 4 MSCT, Then the raw data was reconstructed with lowly kernel(kernel ≤ 30f) and thin slice (slice ≤ 3mm), and transmitted to CT 3D workstation, All images post process were performed by computed tomography virtual endoscopy (CT-VE), Multiplanar reconstructions(MPR), Maximum intensity projection(MIP) and volume reconstruction technique(VRT) software, The manifestations of lesions vessel of MSCT-VIE were analyzed and recorded. <b<Result</b< Among 64 cases, 24 cases of 78 lesions of calcifications, 24 cases with irregular inside wall and thicken of vessels; 21 cases with blood vessel stenosis; 15 cases of 48 lesions with atheromatous spot mass. <b<conclusions</b< the multi-slice CT Virtual Intravascular endoscopy was a valid method to diagnose arteriosclerosises, which was very rapid and noninvasive.