Abstract: Multi-dimensional Stereological Methodology is developed from the research in medical CT and MRI-scanner to display the computerized tomography images for human and animal body,which be used for research in anatomy physiology structure,pathologic characteristic,its theories and methods expansion and application in another science branches,such as the research for industry apparatus and underground structure...etc;Make use of the valid method to research the factors of paroxysm physiology structure,pathologic characteristic,these theories and techniques expensing to many branches;This work may develop the comprehensive predication method,refer to clinical CT application,combined to study the disease control factor,to distinguish the original paroxysm and expect following time-interval,find the precursor of the terminal disease,generalized as " multi-dimensional stereological predication method”,and deducing out a kind of the epistemological method.,which may be contributed to the research of earthquake's pregnancy(seismo-genic structure),and for the prediction of strong earthquake occurrence and volcano’s eruption estimation.