Abstract: Objective To evaluate the value of clinical application of ultrasound and 16 multislice scan in diagnosis of small hepatocellular carcinoma(SHCC). Methods 18 patients with SHCC and 17 patients with benign tumors of liver detected respectively by ultrasound and the high-quality scan mode of 16 multislice scan were compared and analyzed. All cases were confirmed by pathological examinations after the operation and puncturatio. Results: Major cases of SHCC and benign tumors of liver had the typical sonogram features by ultrasonic. Among them, 14 cases of SHCC and 15 cases of benign tumors of liver were diagnosed in coincidence with 16 multislice scan and pathological examinations. However, 3 cases of SHCC had misdiagnosed as 1 case of vascular tumor and 3 cases of hyperlasa noduses, and 3 cases of benign tumors were misdiagnosed as SHCC , 2 cases of constrictive noduses confirmed by CT and pathological examination, but 1 case of inflammatory pseutotumour of liver(IPL) was misdiagnosed also by 16 multislice scan. Conclusion Ultrasonic was the first choice for the routine examination. It had a higher detection rate for benign and malignant tumors of liver. But for some non-typical cases, it still needed further examination using 16 multislice scan and pathological test to enhance the early diagnostic rate.