Abstract: Objective: To research the appearances of multi-slice CT(multi-slice CT MSCT)in pulmonary hamartoma so as to improve the CT diagnostic accuracy. Methods: The CT and pathological findings of 32 cases of pulmonary hamartoma were analyzed. Dynamic contrast enhancement MSCT scanning were performed in 22 cases. All cases were confirmed by surgical operation and pathology. Results: All hamartomas had smooth edge on MSCT. Focal fat without calcification inside were present in 12 of 32 cases(37.5%), focal fat and calcification inside in 8 of 25cases (25%), calcification without fat inside in 2 of 32 cases (6.25%). The CT contrasted value was less than 20 Hu in 20 of 22 cases (90.9%). Contrast-enhancing septa were present in 16 of 22 cases(72.7%). Conclusion: Some specific MSCT features, including smooth edge, calcification and fat inside, are useful for diagnosis of pulmonary hamartoma. Dynamic contrast enhancement MSCT scanning is useful for differentiating pulmonary hamartoma with peripheral lung carcinoma.