Abstract: Objective: This study investigated the application value of personalized contrast agent injection schemes of different durations in improving the image quality of pulmonary artery CTA and reducing the potential risk associated with contrast agents. Materials and Methods: From January 2023 to October 2024, 106 patients with suspected pulmonary embolism were randomly assigned to Groups A and B. Using the independent samples t-test, we compared the CTA values of the superior venae cavae, pulmonary artery trunks, left and right pulmonary arteries, and left atria of the two groups. We also compared the subjective comprehensive evaluations of the CTA image quality of the two groups; a value of P<0.05 was considered statistically significant. Additionally, the two groups were compared in terms of the total amount of contrast agent injection, injection duration, and injection rate. Both the total amount and duration of contrast agent injection in Group B were lower than those in Group A; the concomitant difference was statistically significant. The CTA values of the right and left pulmonary arteries and the left atria of the two groups were relatively close, with no statistically significant difference. However, a statistically significant difference in the CTA values of the superior venae cavae of the two groups was observed. The subjective evaluation of image quality between the two groups indicated a statistically significant difference (P=0.04), with the image quality of Group B being higher than that of Group A. Conclusion: The use of an 8s personalized contrast agent injection regimen can not only improve the overall image quality of pulmonary artery CTA but also reduce the amount of contrast agent used and shorten the injection duration.