Abstract: Objective: Based on phantom experiments, this study aims to optimize artifacts in multimaterial dentures and provide guidance for clinical practice. Method: A blank control and six denture full-crown models of different materials are placed sequentially at the CIRS phantom center. Subsequently, dual-energy CT scanning is performed using energy CT, and the optimal contrast image of the blank control is reconstructed as a baseline. Next, the optimal contrast images are reconstructed under standard and bone algorithms for the six groups, in addition to virtual monochromatic images at 70–140 keV with an interval of 10 keV. CT and SD values are recorded, and the artifact index (AI) is calculated. Routine scanning is performed and radiation doses of the routine and energy groups are recorded. Two radiologists subjectively evaluate the images of each group and perform a variance analysis or nonparametric tests for data analysis. Results: The radiation dose of the energy group (6.15±0.10) mGy is significantly lower than that of the routine group (30.35±0.02) mGy. The consistency of the subjective image scoring is favorable. As the energy levels increase, the image quality of the energy group improves, whereas the AI decreases. Standard algorithm: The AI values of all modules except the upper fat differ significantly. The AI values of all modules except the light bone differ significantly because of the different denture materials used. Bone algorithm: The AI values of all modules differ significantly, and the AI values of fat and muscle differ significantly owing to the different denture materials. Conclusion: Energy CT significantly reduces the radiation dose. Additionally, pure-titanium dentures have the least number of artifacts and are the preferred material for clinical full crowns. Energy CT combined with virtual single-energy imaging can reduce artifacts and optimize image quality. Recommendations for clinical observation of bone tissue are as follows: Pure titanium, 140 keV; cobalt–chromium, 90 keV; cobalt–chromium porcelain, 140 keV; nickel–chromium, 120keV; nickel–chromium porcelain, 120 keV; and all ceramic, 140 keV.