Abstract: Objective Pheochromocytomas present with diverse clinical manifestations, and surgical resection is the optimal treatment. However, intraoperative risks are challenging to assess effectively. Computed tomography (CT) imaging is a crucial tool for localization, diagnosis, and predicting therapeutic efficacy. In recent years, radiomics research based on CT has demonstrated significant advantages and potential applications in tumor differential diagnosis, classification, biological behavior assessment, and intraoperative risk evaluation. Moreover, the development of omics models based on tumor characteristics offers a reliable and non-invasive alternative to guide precision medicine procedures. This study aimed to explore the application and value of CT radiomics in the intraoperative risk assessment of pheochromocytomas, assisting physicians in related departments to better understand the research findings associated with radiomics.