Abstract: Ganglioneuroma (GN) is an extremely rare (1/100000), slow-growing benign tumor. Preoperative diagnosis depends on imaging examination but is sometimes difficult. Computed tomography (CT) has high clinical prevalence and is widely used in the detection and diagnosis of mediastinal diseases. This report summarizes and analyzes the CT manifestations of a case of giant GN of the mediastinum in our hospital, and reviews the relevant literature to improve the CT diagnostic level.