Abstract: Objective: To study the feasibility of energy spectrum purification Sn 150 kV combined with Advanced Simulated Iterative Reconstruction (ADMIRE) in computed tomography (CT) examination of the lumbar spine. Methods: A total of 88 patients aged 25_-65 years with body mass indexes (BMI) between 18.5~25 kg/m² were randomly divided into a control group (group A) and an experimental group (group B), with 44 cases in each group. The conventional tube voltage, used for the control group, was 120 kV, while the experimental tube voltage was Sn 150 kV. All other imaging parameters were consistent. After the inspection, the image quality and radiation dose of the two groups were compared. Results: The objective evaluation of noise in group A and group B were statistically different, with the noise of group A higher than that of group B. The ICC of the three diagnosticians in the subjective evaluation was 0.769, indicating a good consistency of evaluation. The radiation dose of group B was 30.31% lower than that of group A. Conclusion: The combination of energy spectrum purification Sn 150 kV and ADMIRE can not only effectively reduce the radiation dose, but can also guarantee a high-quality image, which can be widely used in adult lumbar CT.