Abstract: Objective: To improve the ability of differential diagnosis of sebaceous carcinoma of eyelid and basal cell carcinoma by investigating their CT and MRI findings. Methods: The clinical data and imaging findings of 14 patients with sebaceous carcinoma of eyelid and 7 patients with basal cell carcinoma confirmed by operation were retrospectively analyzed and compared. Results: Among the 14 patients with SC, 6 cases underwent CT examination, 7 cases underwent the MRI examination, and 1 case underwent both CT and MRI. Among the 7 patients with BCC, 1 case underwent CT examination, and 5 cases underwent the MRI plain scan, and 1 case underwent both CT and MRI. 92.9% of SC cases were female (13/14). 50% of SC were located in the upper eyelid, and most of them were in the shape of ring strip and nodule (12/14). Half of the lesions had unclear boundaries (7/14). The arc sign (5/14) and gas sign (4/7) often appeared in the lesions. One case invaded the adjacent orbital tissue. The proportion of male and female patients in BCC cases was similar. The lesions of BCC were all located in the lower eyelid (7/7). Nearly half of the shape of the lesions was nodular (3/7). Most of them had clear boundaries (6/7). Calcification was found in one case, and no invasion of adjacent tissue was found. Conclusion: There are some differences in epidemiology, location and imaging features between sebaceous carcinoma of eyelid and basal cell carcinoma. Mastering the key points of differentiation between sebaceous carcinoma of eyelid and basal cell carcinoma can improve the accuracy of preoperative qualitative diagnosis.