Abstract: Objective:To explore the value of CT angiography(CTA) combined with blood lipid level in the diagnosis of diabetes mellitus complicated with coronary artery disease. Methods:The clinical data of 73 patients with type 2 diabetes mellitus(T2DM) were retrospectively analyzed, including 38 patients with coronary artery disease(T2DM-CHD group) and 35 patients without coronary artery disease(T2DM group). All patients were routinely tested for blood lipid level, and coronary CTA was performed. Based on the results of CAG, the value of CTA combined with blood lipid level in predicting coronary artery lesions in patients with T2DM was analyzed. Result:TC, TG and LDL-C increased gradually with the occurrence and severity of coronary artery disease(P<0.05), while HDL-C decreased gradually(P<0.05). CTA had a high consistency with CAG in the diagnosis of coronary artery lesions in patients with T2DM(Kappa value=0.752, P=0.000). The sensitivity, specificity, positive predictive value and negative predictive value of combined lipid and CTA examination were significantly higher than those of single lipid and CTA diagnosis, which were 92.31%, 95.15%, 95.34% and 96.37% respectively. Conclusion:CTA detection is helpful to predict the occurrence and severity of CHD, and combined with blood lipid level can improve the detection efficiency of coronary artery lesions in patients with T2DM.