Abstract: Objective:To analyze the image features of tuberculous sclerosis(TSC) in different parts of the skull in CT scan. Method:The data of 16 children with craniocerebral TSC who were treated in this hospital from January 2016 to December 2018, were retrospectively analyzed. The main clinical manifestations and CT imaging features of patients with craniocerebral TSC were analyzed. Results:Epilepsy, hypophrenia and skin damage were the main clinical manifestations of patients with TSC, in which epilepsy was the most typical, and the incidence was 93.75%. There was no statistically significant difference in the accuracy between CT examination and surgical pathology in the diagnosis of TSTC in different parts(P>0.05). CT scan of patients with TSC can be expressed with subependymal nodules, which were shown as strips-like, round or round-shaped calcified nodules, and were symmetrically distributed. More nodules were located in the lateral margin of thebody of lateral ventricle. The plain CT scan of 9 patients with brain parenchymal nodules showed that there were 5 cases with calcified nodules in the cortex and under cortex, which were in the form of sand grains. 1 cases showed punctate or patchy low-density nodular lesions with clear edge. CT scan of 4 patients showed changes in cerebral sulcus and cerebral cistern and showed cortical brain atrophy. CT plain scan showed a localized or generalized widening in the frontal parietal and temporal occipital sulcus. Ventricular dilatation was relatively rare, which mainly showed dilatation of lateral ventricle, and the forehead and occipital angle showed changes obviously like balloon. Conclusion:The main clinical features of patients with TSC are seizures, hypophrenia and skin damage. In CT scan, subventricular part is the most common nodule site in patients with TSC. Nodules in different sites can have characteristic CT features, but intracranial calcified nodule lesions are the most specific signs of TSC in CT plain scan, so CT can be used as one of the first choice for examination of intracranial TSC.