Abstract: Objective:To explore the diagnostic efficacy of dual source CT coronary angiography combined with serum MMP-10 and F-ABP levels(combined diagnosis) for new acute myocardial infarction(AMI). Methods:62 patients with AMI and 60 patients with non AMI cardiovascular disease were enrolled in the Department of Cardiology of our hospital. The levels of MMP-10 and F-ABP were detected by dual source CT coronary angiography. Based on the results of coronary angiography, the diagnostic efficacy of dual source CT coronary angiography combined with serum MMP-10 and f-abp was analyzed. Results:the levels of MMP-10 and F-ABP in the case group were higher than those in the control group(8.32 ±0.26) μg/L vs(5.95 ±0.39) μg/L,(8.59 ±2.34) μg/L vs(4.21 ±1.25) μg/L, P < 0.05. 56 cases of AMI were correctly diagnosed by dual source CT. ROC analysis showed that dual source CT, serum MMP-10, F-ABP and AUC were 0.910, 0.843 and 0.772 respectively. The sensitivity and specificity of dual source CT were 90.32% and 88.33% respectively. The sensitivity and specificity of MMP-10 in the diagnosis of AMI were 79.03% and 83.33% respectively. The sensitivity and specificity of F-ABP in the diagnosis of AMI were 83.87% and 80.00% respectively. The sensitivity and specificity were 98.39% and 100.00%, respectively. Conclusion:dual source CT coronary angiography, serum MMP-10, F-ABP levels have certain diagnostic efficacy for new AMI, the combined diagnosis is closer to the real results, with higher accuracy.