Reliable Study on Computer-aided Evaluation of the Severity of Acute Pulmonary Embolism
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摘要: 目的：评估基于几何的计算机辅助检测、量化急性肺栓塞栓子形态和栓塞严重程度的可靠性。方法：对30例疑似急性肺栓塞患者分别采用人工判读和计算机辅助判读进行血管阻塞指数计算，并对计算机辅助栓塞定量指标进行分析。分别对人工判读和计算机辅助判读Qanadli和Mastora阻塞指数的可靠性进行分析。结果：人工判读和计算机辅助判读时间花费具有统计学差异（Q：（185.83±71.23） s vs.（169.97±69.16） s；M：（374.90±150.16） s vs.（121.07±51.76） s，P<0.001）。人工判读和计算机辅助判读Qanadli阻塞指数的差异为1.83±2.19；97.5%（39/40）的测量值在95%置信区间内（ICC=0.998）。人工判读和计算机辅助判读Mastora阻塞指数的差异为1.46±1.62；97.5%（39/40）的测量值在95%置信区间内（ICC=0.997）。栓子定量指标与Qanadli和Mastora阻塞指数呈中度相关（P均<0.001）。结论：计算机辅助检测和量化有助于提高血管阻塞指数的时效性和可靠性，为疾病评估提供额外的、重要的定量指标。Abstract: To evaluate the reliability of geometry-based computer-aided detection and quantification for emboli morphology and embolism severity of acute pulmonary embolism. Thirty patients suspected acute PE were analyzed by manual and computer-aided interpretation of vascular obstruction index and computer-aided measurements of emboli quantitative indicators, respectively. The reliabilities of Qanadli and Mastora scores using computer-aided and manual interpretation were analyzed. The time costs of manual and computer-aided interpretation were statistically different(Q:(185.83 ±71.23) s vs.(169.97 ±69.16) s; M:(374.90 ±150.16) s vs.(121.07 ±51.76) s,all P < 0.001). The difference between computer-aided and manual interpretation of Qanadli score was 1.83 ±2.19; 97.5%(39/40) of the measurements were within 95% confidence interval(ICC=0.998). The difference between computer-aided and manual interpretation of Mastora score was 1.46 ±1.62; 97.5%(39/40) of the measurements were within 95% confidence interval(ICC=0.997). The emboli quantitative indicators were moderately correlated with Qanadli and Mastora scores(all P < 0.001). Computer-aided detection and quantification could help to improve the timeliness and reliability of vascular obstruction index, and provide additional and significant quantitative indicators for disease assessment.
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