Abstract: Objective:The clinical and chest CT features of COVID-19 cases were analyzed retrospectively. To know more deeply about the disease and promote the diagnosis and treatment of the disease. Method:70 cases of COVID-19 in Dongguan were included. Of all cases, the routine blood test and C-reactive protein test were performed. 69 cases underwent chest CT examinations. The thickness and interval of CT examination were 1.25 mm. CT images were evaluated by the following indications:location and number, distribution, shape, density, internal characteristics, margin, halo sign of intra-pulmonary lesion and extra pulmonary signs. Results:There were 37 males and 33 females with an average age of(41.29 ±17.86) years. 45 cases(64.29%) had fever in the first visit, leukocyte count was normal or decreased in 67 cases(95.71%), lymphocyte count was decreased in 52 cases(74.29%), C-reactive protein value was increased in 43 cases(61.43%). Chest CT image findings:55 cases showed pneumonic imaging signs of all 69 patients underwent CT examinations, including 21 unilateral lung lesions and 34 bilatera multiple lesions. 42 cases were mainly distributed under the peripheral pleura, and the shape of the lesions showed various findings, including flaky or patchy exudation, nodular and stripe shaped lesions. The density of the lesions was nonuniform. 44 cases had indistinct edge and 35 cases had halo sign. In all 55 cases, ground-glass opacity lesions were showed. Reticular lesions were showed in 37 cases. There were 52 cases of abnormal bronchovascular bundles findings and 38 cases of abnormal pleural findings. Conclusion:The clinical and CT manifestations of COVID-19 have certain characteristics. It is not difficult to diagnose COVID-19 with the epidemiological history and CT feature. But the special manifestations and differential diagnosis of the disease should be given attention.