Correlation of T2WI Characteristics with ADC Value and Ki-67 Expression in Young Women with Invasive Ductal Carcinoma
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摘要: 目的：探讨青年女性乳腺浸润性导管癌T2WI特征，联合ADC值与Ki-67表达相关性。方法：选取我院2018年至2019年经手术或穿刺活检证实的青年组浸润性导管癌患者13例（≤35岁）作为研究对象。回顾性分析MRI平扫序列中病灶组织的T2加权信号特征和表观弥散系数（ADC）值，并选取免疫组织化学方法计算出Ki-67（增殖细胞的活性）的百分比值。结果：青年女性乳腺浸润性导管癌组织的ADC值范围为（0.78±0.08）10-3/mm2，所检测的Ki-67的阳性表达率约为92%。在病灶组织中，T2WI呈现稍高信号，与Ki-67的阳性表达率呈正相关，ADC值与Ki-67在一定范围内呈负相关。结论：青年女性乳腺浸润性导管癌MRI检查中T2WI序列信号特征多表现为稍高信号（84%）或等信号（16%）；伴随有ADC值下降至一定范围（<1×10-3/mm2），Ki-67呈现阳性表达率显著增高。T2WI信号特征联合ADC值对青年女性乳腺浸润性导管癌患者的诊断、临床治疗方法的选择及预后的预估有重要参考价值。Abstract: Objective:To explore the correlation between the T2WI characteristics with ADC value and the expression of Ki-67 in young women with invasive breast cancer. Methods:Thirteen young patients (≤ 35 years old) admitted to our hospital from May 2018 to July 2019 were selected as study objects. The T2-weighted signal characteristics and apparent diffusion coefficient (ADC) values of the focus in the MRI scanning sequence were recorded in detail, and the percentage value of Ki-67 (activity of proliferating cells) was calculated by immunohis to chemistry. Results:The ADC value range of young women with invasive breast cancer was (0.78±0.08)×10-3/mm2, and the positive expression rate of Ki-67 detected was about 92%. In the focus, T2WI showed slightly higher signal and positive expression rate of Ki-67 were positively correlated, while ADC value was negatively correlated with Ki-67 within a certain range. The T2WI signal and the quantization value of ADC in the lesions were analyzed to be the factors influencing the positive expression of Ki-67. Conclusion:In young women with invasive breast cancer, the T2WI sequence signal features are mostly slightly high signal (84%) or equal (16%). With ADC value decreasing to a certain range (1×10-3/mm2), Ki-67 presented a significant increase in positive expression. T2WI signal characteristics combined with ADC values have important reference value for diagnosis, clinical treatment selection and prognosis prediction of young female patients with invasive breast cancer.
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Keywords:
- young women /
- breast /
- invasive ductal carcinoma /
- MRI /
- Ki-67
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期刊类型引用(5)
1. 宁宁，梁泓冰，吴祺，王卓，张丽娜. 不同磁共振成像技术在年轻女性乳腺肿瘤的研究进展. 磁共振成像. 2023(02): 186-190 . 
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2. 高洁，王健宝，王纯娜，邹芝香. Ki-67、CyclinD-1及STAT3蛋白在乳腺叶状肿瘤组织中的表达及其临床意义分析. 临床和实验医学杂志. 2023(16): 1736-1740 . 百度学术
3. 吴丽萍，张南，刘文霞. 乳腺癌磁共振参数与表皮生长因子受体2增殖细胞核抗原相关性. 河北医学. 2022(10): 1684-1689 . 百度学术
4. 李华梅，阳光辉，张野，黄丽霞. 乳腺浸润性导管癌与不规则肿块型导管内乳头状瘤的MRI影像表现及特征比较. 医学综述. 2021(08): 1651-1656 . 百度学术
5. 吕雪飞，胡少平. 女性乳腺癌MRI扩散特征与HER-2表达相关性初步研究. CT理论与应用研究. 2020(05): 584-590 . 本站查看
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