Abstract: Current studies have confirmed that spectral CT imaging can be used to evaluate the nature of the lesion. For pulmonary nodules, spectral CT imaging can help to differentiate benign and malignant pulmonary nodules. For lung cancer, spectral CT imaging can also provide information about qualitative, staging and therapeutic effect. This article reviews the clinical application of spectral CT technology for pulmonary nodules, including spectral CT scanning technology of pulmonary nodules, differential diagnosis of pulmonary nodules, staging of lung cancer, correlation with clinical indicators and its application in monitoring curative effect.